2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-Y0337AR
    L-Cysteine hydrochloride (Standard) 52-89-1 98%
    L-Cysteine (hydrochloride) (Standard) is the analytical standard of L-Cysteine (hydrochloride). This product is intended for research and analytical applications. L-Cysteine hydrochloride is an orally active conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine hydrochloride suppresses ghrelin and reduces appetite in rodents. L-Cysteine hydrochloride inhibits Aspergillus flavus growth and AFB synthesis by disrupting cell structure and antioxidant system balance. L-Cysteine hydrochloride enhances relaxant responses of rat aortic rings to NO and reduces responses to endothelium-derived relaxing factor (EDRF)[4].
    L-Cysteine hydrochloride (Standard)
  • HY-Y0337S7
    L-Cysteine-d3,15N 1795787-05-1 98%
    L-Cysteine-d3,15N is the deuterium and 15N-labeled L-Cysteine. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans.
    L-Cysteine-d3,15N
  • HY-Y0504S1
    Trimethylammonium chloride-d10 107766-37-0 98.0%
    Trimethylammonium chloride-d10 is the deuterium labeled Trimethylammonium chloride. Trimethylammonium chloride is an endogenous metabolite.
    Trimethylammonium chloride-d10
  • HY-Y0504S2
    Trimethylammonium chloride-15N 108451-51-0 98%
    Trimethylammonium chloride-15N is the 15N labeled Trimethylammonium chloride. Trimethylammonium chloride is an endogenous metabolite.
    Trimethylammonium chloride-15N
  • HY-Y0836S1
    Diethyl succinate-d4 52089-62-0 98%
    Diethyl succinate-d4 is the deuterium labeled Diethyl succinate. Diethyl succinate (Diethyl Butanedioate) is used at physiological pH and crosses biological membranes, incorporates into cells in tissue culture and is metabolized by the TCA cycle. Diethyl succinate is known to be non-toxic and used in fragrances and flavoring.
    Diethyl succinate-d4
  • HY-Y1809S1
    1-Hydroxyoctadecane-d2 86369-69-9 98%
    1-Hydroxyoctadecane-d2 is the deuterium labeled 1-Hydroxyoctadecane. 1-Hydroxyoctadecane is an endogenous metabolite.
    1-Hydroxyoctadecane-d2
  • HY-100641S1
    4-Hydroxytolbutamide-d9-1
    4-Hydroxytolbutamide-d9-1 (Hydroxytolbutamide-d9-1) is the deuterium labeled 4-Hydroxytolbutamide (HY-100641). 4-Hydroxytolbutamide (Hydroxytolbutamide) is a metabolite of Tolbutamide. 4-Hydroxytolbutamide is metabolized by CYP2C8 and CYP2C9. Tolbutamide is a first generation potassium channel blocker and a sulfonylurea oral antidiabetic.
    4-Hydroxytolbutamide-d9-1
  • HY-101400S1
    Deoxycytidine triphosphate-15N3,d14 dilithium 98%
    Deoxycytidine triphosphate-15N3,d14 (dCTP-15N3,d14 dilithium; 2′-Deoxycytidine-5′-triphosphate-15N3,d14) dilithium is deuterium and 15N labeled Deoxycytidine triphosphate (HY-101400). Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that can be used for DNA synthesis. Deoxycytidine triphosphate has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing.
    Deoxycytidine triphosphate-15N3,d14 dilithium
  • HY-101400S2
    Deoxycytidine triphosphate-13C9,15N3 dilithium 98%
    Deoxycytidine triphosphate-13C9,15N3 (dCTP-13C9,15N3 dilithium; 2′-Deoxycytidine-5′-triphosphate-13C9,15N3) dilithium is 13C and 15N-labeled Deoxycytidine triphosphate (HY-101400). Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that can be used for DNA synthesis. Deoxycytidine triphosphate has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing.
    Deoxycytidine triphosphate-13C9,15N3 dilithium
  • HY-101400S4
    Deoxycytidine triphosphate-13C9 dilithium 98%
    Deoxycytidine triphosphate-13C9 (dCTP-13C9 dilithium; 2′-Deoxycytidine-5′-triphosphate-13C9) dilithium is 13C-labeled Deoxycytidine triphosphate (HY-101400). Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that can be used for DNA synthesis. Deoxycytidine triphosphate has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing.
    Deoxycytidine triphosphate-13C9 dilithium
  • HY-101981S1
    Uridine 5'-monophosphate-15N2,d11 dilithium 98%
    Uridine 5'-monophosphate-15N2,d11 (5'- Uridylic acid-15N2,d11) dilithium is deuterium and 15N labeled Uridine 5'-monophosphate (HY-101981). Uridine 5'-monophosphate (5'-Uridylic acid) is an orally active mitochondrial ATP-dependent potassium channel activator that has a protective effect on the heart. Uridine 5'-monophosphate can promote the synthesis of CDP-choline and induce apoptosis in intestinal epithelial cells, which is beneficial for gut development and reduces diarrhea.
    Uridine 5'-monophosphate-15N2,d11 dilithium
  • HY-101981S3
    Uridine 5'-monophosphate-13C9,15N2 dilithium 2483830-55-1 98%
    Uridine 5'-monophosphate-13C9,15N2 (5'- Uridylic acid-13C9,15N2) dilithium is 13C and 15N-labeled Uridine 5'-monophosphate (HY-101981). Uridine 5'-monophosphate (5'-Uridylic acid) is an orally active mitochondrial ATP-dependent potassium channel activator that has a protective effect on the heart. Uridine 5'-monophosphate can promote the synthesis of CDP-choline and induce apoptosis in intestinal epithelial cells, which is beneficial for gut development and reduces diarrhea.
    Uridine 5'-monophosphate-13C9,15N2 dilithium
  • HY-101981S4
    Uridine 5'-monophosphate-13C9 dilithium 98%
    Uridine 5'-monophosphate-13C9 (5'- Uridylic acid-13C9) dilithium is 13C-labeled Uridine 5'-monophosphate (HY-101981). Uridine 5'-monophosphate (5'-Uridylic acid) is an orally active mitochondrial ATP-dependent potassium channel activator that has a protective effect on the heart. Uridine 5'-monophosphate can promote the synthesis of CDP-choline and induce apoptosis in intestinal epithelial cells, which is beneficial for gut development and reduces diarrhea.
    Uridine 5'-monophosphate-13C9 dilithium
  • HY-101981S5
    Uridine 5'-monophosphate-15N2 dilithium 98.00%
    Uridine 5'-monophosphate-15N2 (5'- Uridylic acid-15N2) dilithium is 15N labeled Uridine 5'-monophosphate (HY-101981). Uridine 5'-monophosphate (5'-Uridylic acid) is an orally active mitochondrial ATP-dependent potassium channel activator that has a protective effect on the heart. Uridine 5'-monophosphate can promote the synthesis of CDP-choline and induce apoptosis in intestinal epithelial cells, which is beneficial for gut development and reduces diarrhea.
    Uridine 5'-monophosphate-15N2 dilithium
  • HY-106577AS
    (-)-(S)-Cibenzoline-d4 98%
    (-)-(S)-Cibenzoline-d4 (Escibenzoline-d4) is deuterium labeled (-)-(S)-Cibenzoline. (-)-(S)-Cibenzoline (Escibenzoline), a S(+)-enantiomer of Cibenzoline, is an antiarrhythmic agent.
    (-)-(S)-Cibenzoline-d4
  • HY-107494AR
    all-trans-4-Oxoretinoic acid (Standard) 38030-57-8
    all-trans-4-Oxoretinoic acid (Standard) is the analytical standard of all-trans-4-Oxoretinoic acid. This product is intended for research and analytical applications. all-trans-4-Oxoretinoic acid, an active metabolite of vitamin A, induces gene transcription via binding to nuclear retinoic acid receptors (RARs).
    all-trans-4-Oxoretinoic acid (Standard)
  • HY-107737S2
    1,2-DLPC-d46 136565-60-1
    1,2-DLPC-d46 (1,2-Dilauroyl-sn-glycero-3-phosphocholine-d46) is the deuterium labeled 1,2-DLPC. 1,2-DLPC (1,2-Dilauroyl-sn-glycero-3-phosphocholine) is a ligand for LRH-1 agonists. 1,2-DLPC is a phospholipid used in the synthesis of liposomes. 1,2-DLPC enhances fat breakdown and apoptosis in fat cells through a TNFα-dependent pathway, while also inhibiting palmitate-induced insulin resistance through PPARα-mediated inflammation in muscle cells.
    1,2-DLPC-d46
  • HY-107737S3
    1,2-DLPC-d9
    1,2-DLPC-d9 (1,2-Dilauroyl-sn-glycero-3-phosphocholine-d9) is the deuterium labeled 1,2-DLPC. 1,2-DLPC (1,2-Dilauroyl-sn-glycero-3-phosphocholine) is a ligand for LRH-1 agonists. 1,2-DLPC is a phospholipid used in the synthesis of liposomes. 1,2-DLPC enhances fat breakdown and apoptosis in fat cells through a TNFα-dependent pathway, while also inhibiting palmitate-induced insulin resistance through PPARα-mediated inflammation in muscle cells.
    1,2-DLPC-d9
  • HY-107855S1
    DL-Mevalonolactone-d3 61219-76-9 98%
    DL-Mevalonolactone-d3 is the deuterium labeled DL-Mevalonolactone. DL-Mevalonolactone ((±)-Mevalonolactone;Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone (Mevalonolactone) decreases mitochondrial membrane potential ( Ψm), NAD(P)H content and the capacity to retain Ca2+ in the brain, besides inducing mitochondrial swelling.
    DL-Mevalonolactone-d3
  • HY-107855S2
    DL-Mevalonolactone-13C 53771-22-5
    DL-Mevalonolactone-13C ((±)-Mevalonolactone-13C) is the 13C-labeled DL-Mevalonolactone (HY-107855). DL-Mevalonolactone ((±)-Mevalonolactone;Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone is orally active against HMGCR mutation and statin caused myopathy. DL-Mevalonolactone induces inflammation and oxidative stress response with decreased mitochondrial membrane potential (MMP) and induces mitochondrial swelling.
    DL-Mevalonolactone-13C
Cat. No. Product Name / Synonyms Application Reactivity